The Enterprise Initiative is a research program that supports rigorous methods to examine the complex process of wealth creation and the role of enterprise in alleviating poverty. The Initiative, funded by a $3.3 million grant, explores entrepreneurship in developing economies through the lens of Applied General Equilibrium Enterprise Economics (AGE-3). Using analytic economic modeling, researchers closely study human entrepreneurial talent and the attitudes that contribute to economic success, not only at the individual level but also at the village, regional and national levels. This collaborative research initiative leverages NICHD and NSF funding for data collection and brings together researchers and faculty from a variety of subfields at the University of Chicago in the Department of Economics and the Computation Institute, the Poverty Action Lab at MIT and the Economic Growth Center at Yale University.